[HTML][HTML] Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome
CC Goulet, KA Volk, CM Adams, LS Prince… - Journal of Biological …, 1998 - ASBMB
The epithelial Na+ channel (ENaC) plays a critical role in Na+ absorption in the kidney and
other epithelia. Mutations in the C terminus of the β or γENaC subunits increase renal Na+
absorption, causing Liddle's syndrome, an inherited form of hypertension. These mutations
delete or disrupt a PY motif that was recently shown to interact with Nedd4, a ubiquitin-
protein ligase expressed in epithelia. We found that Nedd4 inhibited ENaC when they were
coexpressed in Xenopusoocytes. Liddle's syndrome-associated mutations that prevent the …
other epithelia. Mutations in the C terminus of the β or γENaC subunits increase renal Na+
absorption, causing Liddle's syndrome, an inherited form of hypertension. These mutations
delete or disrupt a PY motif that was recently shown to interact with Nedd4, a ubiquitin-
protein ligase expressed in epithelia. We found that Nedd4 inhibited ENaC when they were
coexpressed in Xenopusoocytes. Liddle's syndrome-associated mutations that prevent the …
