[HTML][HTML] STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output
G Li, Z Wang, Y Zhang, Z Kang, E Haviernikova… - Experimental …, 2007 - Elsevier
OBJECTIVE: Signal transducer and activator of transcription 5 (STAT5) is a critical regulator
of hematopoietic development and its impaired activation is associated with hematopoietic
and immune cell defects. However, much of this information has been learned from knockout
mice that still retain the potential for expression of STAT5 proteins that are N-terminally
truncated due to alternative internal translation initiation codons. The goal of these studies
was to use transplantation-based assays to analyze the degree of STAT5ΔN activity in …
of hematopoietic development and its impaired activation is associated with hematopoietic
and immune cell defects. However, much of this information has been learned from knockout
mice that still retain the potential for expression of STAT5 proteins that are N-terminally
truncated due to alternative internal translation initiation codons. The goal of these studies
was to use transplantation-based assays to analyze the degree of STAT5ΔN activity in …
