Immunotherapy with Mycobacterium vaccae as an adjunct to chemotherapy in the treatment of pulmonary tuberculosis

JL Stanford, GM Bahr, GAW Rook, MA Shaaban… - Tubercle, 1990 - Elsevier
Abstract 47 patients with adult-type pulmonary tuberculosis attending the Chest Diseases
Hospital in Kuwait were given a single injection of 10 9 irradiation-killed M. vaccae after 1
month of a 9-month course of chemotherapy. The patients were followed-up for 3 more
months in double blind comparison with 65 patients given an injection of saline (placebo).
The immunotherapeutic injection produced a small local lesion in 44/47 patients, 18 of
which ulcerated and produced small scars. Immunotherapy made no measurable difference …