RUTI: a new chance to shorten the treatment of latent tuberculosis infection
PJ Cardona - Tuberculosis, 2006 - Elsevier
Treatment of latent tuberculosis infection (LTBI) requires a long period of chemotherapy (9
months), which makes treatment-compliance extremely difficult. Current knowledge of latent
bacilli and of the lesions with which they are associated suggests that these bacilli survive in
granulomas with a central necrotic core and an outermost layer of foamy macrophages (FM)
that represent an important immunosuppressive barrier. The presence of FM, which is
especially strong in mice, explains not only the kinetics of the drainage of dead bacilli, debris …
months), which makes treatment-compliance extremely difficult. Current knowledge of latent
bacilli and of the lesions with which they are associated suggests that these bacilli survive in
granulomas with a central necrotic core and an outermost layer of foamy macrophages (FM)
that represent an important immunosuppressive barrier. The presence of FM, which is
especially strong in mice, explains not only the kinetics of the drainage of dead bacilli, debris …
