[HTML][HTML] Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
Y Kanai, H Segawa, K Miyamoto, H Uchino… - Journal of Biological …, 1998 - ASBMB
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel
Na+-independent neutral amino acid transporter designated LAT1. For functional
expression in Xenopusoocytes, LAT1 required the heavy chain of 4F2 cell surface antigen
(CD98), a type II membrane glycoprotein. When co-expressed with 4F2 heavy chain, LAT1
transported neutral amino acids with branched or aromatic side chains and did not accept
basic amino acids or acidic amino acids. The transport via LAT1 was Na+-independent and …
Na+-independent neutral amino acid transporter designated LAT1. For functional
expression in Xenopusoocytes, LAT1 required the heavy chain of 4F2 cell surface antigen
(CD98), a type II membrane glycoprotein. When co-expressed with 4F2 heavy chain, LAT1
transported neutral amino acids with branched or aromatic side chains and did not accept
basic amino acids or acidic amino acids. The transport via LAT1 was Na+-independent and …
