[HTML][HTML] Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy
T Khoury, FO Ademuyiwa, R Chandraseekhar… - Modern Pathology, 2012 - Elsevier
Studies have shown that ALDH1A1 expression in the breast is associated with worse clinical
outcome. ALDH1A1 inactivates cyclophosphamide, which is an integral agent in breast
cancer chemotherapy regimens. The purposes of this study were to verify these results, to
correlate ALDH1A1 expression with clinical outcome in patients treated with
cyclophosphamide as part of the chemotherapy (adjuvant or neoadjuvant), and to evaluate
ALDH1A1 as a useful marker to predict the clinical outcome of breast cancer subsets. A total …
outcome. ALDH1A1 inactivates cyclophosphamide, which is an integral agent in breast
cancer chemotherapy regimens. The purposes of this study were to verify these results, to
correlate ALDH1A1 expression with clinical outcome in patients treated with
cyclophosphamide as part of the chemotherapy (adjuvant or neoadjuvant), and to evaluate
ALDH1A1 as a useful marker to predict the clinical outcome of breast cancer subsets. A total …