Selenium in the redox regulation of the Nrf2 and the Wnt pathway
R Brigelius-Flohé, AP Kipp - Methods in enzymology, 2013 - Elsevier
Selenium deficiency is known to increase cancer risk by so far unclear mechanisms.
Selenium exerts its biological effects via selenocysteine as an integral part of
selenoproteins. Certain selenoproteins have redox properties, thereby providing a tool to
regulate hydroperoxide-mediated signaling. Selenium deficiency does not only reduce
synthesis of selenoproteins but also affects the expression of other proteins and even
pathways. A moderate Se deficiency activates the Nrf2 and the Wnt pathways. The link …
Selenium exerts its biological effects via selenocysteine as an integral part of
selenoproteins. Certain selenoproteins have redox properties, thereby providing a tool to
regulate hydroperoxide-mediated signaling. Selenium deficiency does not only reduce
synthesis of selenoproteins but also affects the expression of other proteins and even
pathways. A moderate Se deficiency activates the Nrf2 and the Wnt pathways. The link …
