Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the …
In this paper, we review data of recent literature on the distribution in centenarians of
candidate germ-line polymorphisms that likely affect the individual chance to reach the
extreme limit of human life. On the basis of previous observations on the immunology,
endocrinology and cellular biology of centenarians we focused on genes that regulate
immune responses and inflammation (IL-6, IL-1 cluster, IL-10), genes involved in the
insulin/IGF-I signalling pathway and genes that counteract oxidative stress (PON1). On the …
candidate germ-line polymorphisms that likely affect the individual chance to reach the
extreme limit of human life. On the basis of previous observations on the immunology,
endocrinology and cellular biology of centenarians we focused on genes that regulate
immune responses and inflammation (IL-6, IL-1 cluster, IL-10), genes involved in the
insulin/IGF-I signalling pathway and genes that counteract oxidative stress (PON1). On the …