Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
KJ Williams, BA Telfer, D Xenaki, MR Sheridan… - Radiotherapy and …, 2005 - Elsevier
BACKGROUND AND PURPOSE: To test the hypothesis that deficiency in expression of the
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient
tumours. PATIENTS AND METHODS: Tumours comprising mouse hepatoma cells lacking
HIF-1β (and thereby HIF-1 function) were grown in nude mice and radiation-induced growth
delay compared with that seen for wild-type tumours and tumours derived from HIF-1β
negative cells where HIF-1 function had been restored. RESULTS: The xenografts that lack …
transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient
tumours. PATIENTS AND METHODS: Tumours comprising mouse hepatoma cells lacking
HIF-1β (and thereby HIF-1 function) were grown in nude mice and radiation-induced growth
delay compared with that seen for wild-type tumours and tumours derived from HIF-1β
negative cells where HIF-1 function had been restored. RESULTS: The xenografts that lack …