Variation in the incidence and magnitude of tumor-infiltrating lymphocytes in breast cancer subtypes: a systematic review
SE Stanton, S Adams, ML Disis - JAMA oncology, 2016 - jamanetwork.com
Importance The presence of tumor-infiltrating lymphocytes (TILs) is a favorable prognostic
factor in breast cancer, and TILs may synergize with chemotherapy and immune checkpoint
inhibitor therapy for improved clinical response. A more detailed understanding of the
variation in lymphocytic infiltration in breast cancer may aid in identifying subtypes more
amenable to immunomodulation. Objective To determine the median percentage of patients
with breast cancer with no, intermediate, or high levels of TIL and assess variations in …
factor in breast cancer, and TILs may synergize with chemotherapy and immune checkpoint
inhibitor therapy for improved clinical response. A more detailed understanding of the
variation in lymphocytic infiltration in breast cancer may aid in identifying subtypes more
amenable to immunomodulation. Objective To determine the median percentage of patients
with breast cancer with no, intermediate, or high levels of TIL and assess variations in …