Thermogenic and antiobesity activity of a novel β-adrenoceptor agonist (BRL 26830A) in mice and rats
JR Arch, AT Ainsworth - The American journal of clinical nutrition, 1983 - Elsevier
The effects of a novel compound, BRL 26830A, on energy balance in normal and obese
mice have been investigated. BRL 26830A reduced body weight or weight gain in
genetically (ob/ob), goldthioglucose, and cafeteria diet obese mice and genetically obese
(fa/fa) Zucker rats. Weight reduction was due to reduced body lipid content. BRL 26830A
caused little or no reduction in food intake in these animals but it increased metabolic rate
and in genetically obese mice this thermic effect was increased by repeat dosing. BRL …
mice have been investigated. BRL 26830A reduced body weight or weight gain in
genetically (ob/ob), goldthioglucose, and cafeteria diet obese mice and genetically obese
(fa/fa) Zucker rats. Weight reduction was due to reduced body lipid content. BRL 26830A
caused little or no reduction in food intake in these animals but it increased metabolic rate
and in genetically obese mice this thermic effect was increased by repeat dosing. BRL …