Effect of vancomycin or daptomycin with vs without an antistaphylococcal β-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA …
Importance Methicillin-resistantStaphylococcus aureus (MRSA) bacteremia is associated
with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has
been associated with reduced mortality, although adequately powered randomized clinical
trials of this intervention have not been conducted. Objective To determine whether
combining an antistaphylococcal β-lactam with standard therapy is more effective than
standard therapy alone in patients with MRSA bacteremia. Design, Setting, and Participants …
with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has
been associated with reduced mortality, although adequately powered randomized clinical
trials of this intervention have not been conducted. Objective To determine whether
combining an antistaphylococcal β-lactam with standard therapy is more effective than
standard therapy alone in patients with MRSA bacteremia. Design, Setting, and Participants …