Bone, inflammation, and inflammatory bowel disease
Current osteoporosis reports, 2011•Springer
Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease
(IBD). Bone loss is an early systemic process and occurs even before clinical disease
manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic
inflammation. In this review, we discuss the molecular pathways of bone loss mediated by
inflammatory cytokines and other mediators. Further research will hopefully clarify the
mechanisms of inflammation-induced bone loss in IBD and guide effective treatment …
(IBD). Bone loss is an early systemic process and occurs even before clinical disease
manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic
inflammation. In this review, we discuss the molecular pathways of bone loss mediated by
inflammatory cytokines and other mediators. Further research will hopefully clarify the
mechanisms of inflammation-induced bone loss in IBD and guide effective treatment …
Abstract
Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.
Springer
