OBJECTIVES: To identify risk factors for recurrent urinary tract infection (UTI) and renal
scarring in children who have had 1 or 2 febrile or symptomatic UTIs and received no
antimicrobial prophylaxis. METHODS: This 2-year, multisite prospective cohort study
included 305 children aged 2 to 71 months with vesicoureteral reflux (VUR) receiving
placebo in the RIVUR (Randomized Intervention for Vesicoureteral Reflux) study and 195
children with no VUR observed in the CUTIE (Careful Urinary Tract Infection Evaluation) …