Chylomicronemia elicits atherosclerosis in mice—brief report
MM Weinstein, L Yin, Y Tu, X Wang, X Wu… - … , and vascular biology, 2010 - Am Heart Assoc
Arteriosclerosis, thrombosis, and vascular biology, 2010•Am Heart Assoc
Objective—The risk of atherosclerosis in the setting of chylomicronemia has been a topic of
debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient
mice (Gpihbp1−/−), which manifest severe chylomicronemia as a result of defective lipolysis.
Methods and Results—Gpihbp1−/− mice on a chow diet have plasma triglyceride and
cholesterol levels of 2812±209 and 319±27 mg/dL, respectively. Even though nearly all of
the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed …
debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient
mice (Gpihbp1−/−), which manifest severe chylomicronemia as a result of defective lipolysis.
Methods and Results—Gpihbp1−/− mice on a chow diet have plasma triglyceride and
cholesterol levels of 2812±209 and 319±27 mg/dL, respectively. Even though nearly all of
the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed …
Objective— The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1−/−), which manifest severe chylomicronemia as a result of defective lipolysis.
Methods and Results— Gpihbp1−/− mice on a chow diet have plasma triglyceride and cholesterol levels of 2812±209 and 319±27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient “apo-B48–only” mice and Gpihbp1-deficient “apo-B100–only” mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48– and apo-B100–containing lipoproteins.
Conclusions— Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48– and apo-B100–containing lipoproteins.
Am Heart Assoc
