[HTML][HTML] Blinded by the light: the growing complexity of p53
KH Vousden, C Prives - Cell, 2009 - cell.com
KH Vousden, C Prives
Cell, 2009•cell.comWhile the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated.
This burgeoning range of responses to p53 is reflected by an increasing variety of
mechanisms through which p53 can function, although the ability to activate transcription
remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for
determining which p53 response is activated, a decision we must understand if we are to …
p53 to numerous other aspects of disease and normal life is only now being appreciated.
This burgeoning range of responses to p53 is reflected by an increasing variety of
mechanisms through which p53 can function, although the ability to activate transcription
remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for
determining which p53 response is activated, a decision we must understand if we are to …
While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53.
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