Posttranslational modifications of RAS proteins
I Ahearn, M Zhou, MR Philips - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
I Ahearn, M Zhou, MR Philips
Cold Spring Harbor perspectives in medicine, 2018•perspectivesinmedicine.cshlp.orgThe three human RAS genes encode four proteins that play central roles in oncogenesis by
acting as binary molecular switches that regulate signaling pathways for growth and
differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify
their activity or are required for membrane targeting. The enzymes that catalyze the various
PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the
focus of this review.
acting as binary molecular switches that regulate signaling pathways for growth and
differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify
their activity or are required for membrane targeting. The enzymes that catalyze the various
PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the
focus of this review.
The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.
perspectivesinmedicine.cshlp.org