[HTML][HTML] DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H-and N-Ras
JT Swarthout, S Lobo, L Farh, MR Croke… - Journal of Biological …, 2005 - ASBMB
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras
proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine;
H-Ras and N-Ras are further modified by palmitoylation. Yeast Ras is palmitoylated by the
DHHC cysteine-rich domain-containing protein Erf2 in a complex with Erf4. Here we report
that H-and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the
ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC …
proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine;
H-Ras and N-Ras are further modified by palmitoylation. Yeast Ras is palmitoylated by the
DHHC cysteine-rich domain-containing protein Erf2 in a complex with Erf4. Here we report
that H-and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the
ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC …