[HTML][HTML] An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis
SO Abegunde, R Buckstein, RA Wells… - Experimental hematology, 2018 - Elsevier
Clonal hematopoiesis of aging and indeterminate potential (ARCH or CHIP), driven mainly
by mutations in DNMT3A and TET2, is an emerging public health issue, affecting at least 10–
15% of adults older than 65 years. CHIP is associated with increased risks of de novo and
therapy-related hematological neoplasms and serves as a reservoir for leukemic relapse.
CHIP is also associated with increased all-cause mortality and risk of cardio-metabolic
disease. The latter association may be explained, at least in part, by the effects of …
by mutations in DNMT3A and TET2, is an emerging public health issue, affecting at least 10–
15% of adults older than 65 years. CHIP is associated with increased risks of de novo and
therapy-related hematological neoplasms and serves as a reservoir for leukemic relapse.
CHIP is also associated with increased all-cause mortality and risk of cardio-metabolic
disease. The latter association may be explained, at least in part, by the effects of …